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. 2020 Jan 13;102(5):1055–1064. doi: 10.1093/biolre/ioaa008

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Pten^d/d Trp53^d/d TgK19GT₁₂₁ and Pten^d/d Trp53^d/d Cdh1^d/d TgK19GT₁₂₁ mice possess many histopathological features of OvCa in common. Representative images are presented for: (a) epithelial hyperplasia (black arrow), (b, c) progression of micropapillary and papillary carcinomas, (d) papillary structure with slit-like spaces, (e) papillary architecture with cytosolic atypia, (f) high-grade serous carcinoma (HGSC), (g–j) representative features of HGSC with (g) nuclear atypia (black arrows), (h) apoptotic cells (black arrow), (i) abnormal mitosis (black arrows), (j) cell clumps (black arrow), (k) cribriform architecture, (l) granulosa cell tumor, (m) papillary architecture with necrosis, (n) necrotic tumor, (o) papillary with cystic features, (p) peritoneal metastatic tumor, and (q) normal oviduct.