Table 1.
Characteristics of Ptend/d Trp53d/d TgK19GT121 and Ptend/d Trp53d/d Cdh1d/d TgK19GT121 mice.
| Genotype | Phenotype | Age | ||||
|---|---|---|---|---|---|---|
| 1 month | 2 months | 3 months | 4 months | 6 months | ||
| Ptend/d Trp53d/d TgK19GT121 | OSE hyperplasia | 71.4% (5/7) | 11.1% (1/9) | 0% | 0% | 50.0% (3/6) |
| Serous papillary carcinomas | 57.1% (4/7) | 44.4% (4/9) | 71.4% (5/7) | 100.0% (5/5) | 50.0% (3/6) | |
| HGSC | 0% | 0% | 14.3% (1/7) | 60.0% (3/5) | 16.7% (1/6) | |
| Peritoneal metastasis | 0% | 0% | 0% | 60.0% (3/5) | 0% | |
| Ascites fluid accumulation | 0% | 0% | 0% | 20.0% (1/5) | 0% | |
| Granulosa cell tumors | 0% | 11.1% (1/9) | 0% | 0% | 33.3% (2/6) | |
| Necrotic tumors | 0% | 0% | 14.3% (1/7) | 0% | 0% | |
| Uterine tumors | 0% | 0% | 0% | 0% | 16.7% (2/6) | |
| OSE hyperplasia | 0% (0/8) | 30.0% (3/9) | 25.0% (1/4) | 0% | 0% | |
| Serous papillary carcinomas | 0% | 44.4% (4/9) | 75.0% (3/4) | 80.0% (4/5) | 69.2% (9/13) | |
| Pten d/d Trp53 d/d | HGSC | 0% | 0% | 0% | 20.0% (1/5) | 38.5% (5/13) |
| Cdh1 d/d | Peritoneal metastasis | 0% | 0% | 0% | 40.0% (2/5) | 38.5% (5/13) |
| TgK19GT 121 | Ascites fluid accumulation | 0% | 0% | 0% | 40.0% (2/5) | 38.5% (5/13) |
| Granulosa cell tumors | 0% | 0% | 0% | 0% | 0% | |
| Necrotic tumors | 0% | 0% | 0% | 20.0% (1/5) | 0% | |
| Uterine tumors | 0% | 0% | 0% | 0% | 61.5% (8/13) | |