Table 2.
Demographic and Clinical Characteristics of Patients by Infection Site
| Characteristic | Pulmonary NTM (n = 185) | Disseminated NTM (n = 40) | Extrapulmonary NTMa (n = 140) |
|---|---|---|---|
| Age (Years) | |||
| Median | 63 | 42 | 44 |
| Range | 3–95 | 1–87 | 1–88 |
| Gender | |||
| Female | 101 (55) | 13 (33) | 79 (56) |
| Male | 84 (45) | 27 (68) | 61 (44) |
| Race | |||
| White | 168 (91) | 31 (78) | 123 (88) |
| Black | 4 (2) | 7 (18) | 4 (3) |
| Hispanic | 3 (2) | 1 (3) | 6 (4) |
| Asian | 6 (3) | 0 | 0 |
| Comorbidities | |||
| Structural lung diseaseb | 112 (61) | 0 | 4 (3) |
| Solid malignancy | 36 (19) | 7 (18) | 16 (11) |
| Hematologic malignancy | 12 (6) | 9 (23) | 15 (11) |
| Solid organ transplant | 8 (4) | 2 (5) | 4 (3) |
| Hematopoietic stem cell transplant | 6 (3) | 1 (3) | 4 (3) |
| HIV | 15 (8) | 26 (65) | 1 (1) |
| Iatrogenicc | 1 (1) | 9 (23) | 50 (34) |
| Severe neutropeniad | 2 (1) | 5 (13) | 3 (2) |
| Risk factors | |||
| Current smoker | 101 (55) | 20 (50) | 34 (24) |
| Immunosuppressive medicatione | 34 (18) | 6 (15) | 38 (27) |
| IV drug use | 6 (3) | 5 (13) | 5 (4) |
| Treatmentf | |||
| Medical | 129 (70) | 28 (70) | 89 (64) |
| Surgical | 13 (7) | 5 (13) | 92 (66) |
| Outcome | |||
| Resolved | 60 (32) | 8 (20) | 120 (86) |
| Persistent infection | 60 (32) | 3 (8) | 4 (3) |
| Deceased from NTM | 20 (11) | 20 (50) | 3 (2) |
Abbreviations: HIV, human immunodeficiency virus; IV, intervenous; NTM, nontuberculous mycobacteria.
NOTE: Values represent number of patients (%).
aNondisseminated, extrapulmonary infections.
bChronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, interstitial lung disease.
cInfections directly related to diagnostic and therapeutic procedures performed on the patient.
dAbsolute neutrophil count ≤500 cells/mm3.
eSystemic corticosteroids at doses equivalent to ≥15 mg/day prednisone ≥1 month, tumor necrosis factor inhibitors, and noncorticosteroid immunosuppressive agents including immunophilin-binding drugs, antimetabolites, and alkylating agents.
fIndicates whether patients’ treatment course included antimicrobial therapy or surgical intervention. Patients could be included in more than 1 category.