Table 2.
Summarizes other possible therapeutic compounds in SARS-CoV-2 infection.
| Drug | Mechanism of action | Trial/Phase |
|---|---|---|
| Recombinant form of the ACE2 (Khan et al., 2017) | Inhibition of viral adhesion to host cells | |
| Camostat mesylate (Kawase et al., 2012; COVID-19 Clinical Trials, 2020) | Inhibition of viral entry by inhibition of TMPRSS2 | NCT04321096 Phase1/2 |
| Favipiravir (COVID-19 Clinical Trials, 2020; Dong et al., 2020b) | RNA-dependent RNA polymerase inhibition | NCT04358549, Phase 2 |
| Eculizumab (Gralinski et al., 2018; COVID-19 Clinical Trials, 2020) | C5 complement inhibitor | NCT04288713 |
| Neutralizing Antibodies (47D11) (Wang et al., 2020d) | Interaction with Spike protein | |
| Ivermectin (Caly et al., 2020; COVID-19 Clinical Trials, 2020) | Inhibition of in vitro replication | NCT04390022, Phase 2 |
| Corticosteroids: Methylprednisolone (Russell et al., 2020; Wu et al., 2020), Dexamethasone (RECOVERY trial, 2020) | Immunosuppression | NCT04273321, NCT04381936 Phase 2/3 |