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. 2020 Jun 20;286:198070. doi: 10.1016/j.virusres.2020.198070

Table 2.

Summarizes other possible therapeutic compounds in SARS-CoV-2 infection.

Drug Mechanism of action Trial/Phase
Recombinant form of the ACE2 (Khan et al., 2017) Inhibition of viral adhesion to host cells
Camostat mesylate (Kawase et al., 2012; COVID-19 Clinical Trials, 2020) Inhibition of viral entry by inhibition of TMPRSS2 NCT04321096 Phase1/2
Favipiravir (COVID-19 Clinical Trials, 2020; Dong et al., 2020b) RNA-dependent RNA polymerase inhibition NCT04358549, Phase 2
Eculizumab (Gralinski et al., 2018; COVID-19 Clinical Trials, 2020) C5 complement inhibitor NCT04288713
Neutralizing Antibodies (47D11) (Wang et al., 2020d) Interaction with Spike protein
Ivermectin (Caly et al., 2020; COVID-19 Clinical Trials, 2020) Inhibition of in vitro replication NCT04390022, Phase 2
Corticosteroids: Methylprednisolone (Russell et al., 2020; Wu et al., 2020), Dexamethasone (RECOVERY trial, 2020) Immunosuppression NCT04273321, NCT04381936 Phase 2/3