Table 1.
Kidney and SPK transplant recipients admitted with acute rejection within 1 week of stay-at-home state orders during COVID-19 pandemic
Pt | Sex | Age (yr) | Race | Time since transplant (yr) | Transplant type | Induction | Cause of ESRD | Maintenance IS | Scr baseline (mg/dl) | Nonadherence | Presentation | Scr at presentation (mg/dl) | Biopsy | Treatment | Outcomes |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 43 | W | 5 | LUKT | rATG | PCKD | T/M/P | 1.6 | Yes | Nausea, vomiting | 30 | ND | None | Dialysis |
2 | M | 37 | AA | 7 | LUKT | IL-2 (−) | HTN | T/M/P | 1.3 | Yes | Nausea, vomiting | 16 | TCMR | Pulse steroids | Dialysis |
3 | M | 38 | W | 11 | SPK | rATG | DM | T/M/P | 1 | Yes | Nausea, vomiting | 1.5 | ND | None | Failed pancreas |
4 | F | 22 | W | 5 | DD | rATG | MCKD | T/M/P | 0.9 | Yes | Elevated UPC | 1 | ABMR | Pulse steroids i.v. Ig | |
5 | F | 37 | W | 3 | LUKT | rATG | HTN | T/M/P | 1.5 | Yes | Elevated creatinine | 2.5 | Mixed | Pulse steroids i.v. Ig | |
6 | F | 59 | AA | 5 | DD | rATG | HTN | T/L/P | 2 | Yes | Elevated creatinine | 3 | ABMR | Increase baseline IS |
AA, African American; ABMR, antibody-mediated rejection; COVID-19, coronavirus disease 2019; DD, deceased donor; DM, diabetes mellitus; ESRD, end-stage renal disease; F, female; HTN, hypertension; IL-2 (−), interleukin-2 blockade; IS, immunosuppression; LUKT, living unrelated kidney transplant; M, male; MCKD, medullary cystic kidney disease; ND, not done; PCKD, polycystic kidney disease; Pt, patient; rATG, rabbit antithymocyte globulin; Scr, serum creatinine; SPK, simultaneous pancreas-kidney transplantation; TCMR, T cell–mediated rejection; T/L/P, tacrolimus, leflunomide, prednisone; T/M/P, tacrolimus, mycophenolate, prednisone; UPC, urine protein-creatinine ratio; W, white.