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. 2020 Jun 20;41(8):518–530. doi: 10.1016/j.tips.2020.06.001

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© 2020 Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

T Cell Receptor (TCR) Repertoire Profiling Workflow in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Studies and Applications.

(A) RNA/DNA can be isolated from peripheral blood collected from SARS-CoV-2 infected/vaccinated individuals. (B) Peripheral blood RNA/DNA will be used as an input for TCR sequencing library preparation. (C) TCR sequencing will be done using Illumina or other sequencing platforms and resulting data analyzed using popular bioinformatic tools to characterize the TCR repertoire of SARS-CoV-2 infected/vaccinated individuals. (D) The information obtained can be used to advance immunotherapy development, characterize TCR repertoires in specific populations, and monitor herd immunity.