Table III.

Detailed end point definition

Primary end points

30-d MACCE:

Cardiac death

Myocardial re-infarction

Emergency coronary revascularization, including PCI, thrombolysis, and CABG

Stroke

Secondary end points

1. Each component of the primary end point

2. 30-d severe STEMI complications:

Cardiogenic shock (Killip IV)

Acute left heart failure (Killip II, III)

Mechanical complications: including interventricular septum perforation, papillary muscle dysfunction, ruptured left ventricular free walls

Malignant arrhythmia: including ventricular fibrillation, ventricular flutter, ventricular tachycardia, ventricular premature contraction (frequent, polymorphic, multifocal, or R on T)

3. BARC type III and V major bleeding:

BARC IIIa: overt bleeding with hemoglobin drop of 3 to <5 g/dL or any transfusion with overt bleeding

BARC IIIb: overt bleeding with hemoglobin drop >5 g/dL, cardiac tamponade, bleeding that requires surgical intervention to control (excluding dental, nasal, skin, or hemorrhoid), or bleeding that requires intravenous vasoactive agents

BARC IIIc: intracranial hemorrhage (including intraspinal bleeding, excluding microbleeds or hemorrhagic transformation), subcategories confirmed by autopsy/imaging/lumbar puncture, or intraocular bleeding comprising vision

BARC V: fatal bleeding

4. 1-y MACCE

Cardiac death

Myocardial reinfarction

Emergency coronary revascularization, including PCI, thrombolysis, and CABG

Stroke

5. 1-y rehospitalization due to heart failure

6. 1-y all-cause death

7. In-stent thrombosis:

Acute: <24 h

Subacute: 1-30 d

Late: 1-12 m

8. ECG evaluation of myocardial reperfusion and no-reflow: ST-segment resolution and occurrence of no-reflow in ECG at 2 h, 24 h, and 7 d after revascularization therapy

CABG, coronary artery bypass grafting.