Table 2. Cox and LASSO regression analysis for OS in patients with OSCC from GSE42743.
| Characteristics | Univariate analysis | LASSO | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| SPRR3 expression High expression |
0.801 [0.662–0.969] | 0.032 | (+) | 0.865 [0.754–0.992] | 0.037 |
| CSTA expression High expression |
0.924 [0.759–1.126] | 0.435 | |||
| EVPL expression High expression |
0.741 [0.480–1.146] | 0.178 | |||
| PPL expression High expression |
0.771 [0.616–0.965] | 0.023 | (−) | ||
| TGM1 expression High expression |
0.801 [0.662–0.969] | 0.022 | (−) | ||
| Age (years) ≥60 |
1.001 [0.978–1.025] | 0.920 | |||
| Gender Male |
0.694 [0.347–1.386] | 0.300 | |||
| Smoking Current |
1.032 [0.686–1.552] | 0.881 | |||
| T stage T3–4 |
1.39 [0.978–1.965] | 0.067 | |||
| N stage Non N0 |
1.970 [1.370–2.832] | <0.001 | (+) | 1.750 [1.202–2.548] | 0.003 |
Note:
T, primary tumor; N, regional lymph nodes; (+), selected by LASSO regression; (−), abandoned by LASSO regression. The bold characters refers to the P-values of indicators that were statistically significant in the regression models.