Table 3. Cox and LASSO regression analysis for OS in patients with OSCC from TCGA.
| Characteristics | Univariate analysis | LASSO | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| SPRR3 expression High expression |
0.595 [0.371–0.955] | 0.032 | (+) | 0.544 [0.329–0.899] | 0.017 |
| Age (years) ≥60 yr |
1.086 [0.676–1.745] | 0.734 | |||
| Gender Male |
0.788 [0.448–1.272] | 0.329 | |||
| Alcohol history Yes |
1.363 [0.806–2.305] | 0.247 | |||
| HPV infection Positive |
1.138 [0.518–2.497] | 0.748 | |||
| Radiation therapy Yes |
0.639 [0.398–1.025] | 0.063 | |||
| Histologic grade Moderate and Poor |
1.549 [0.760–3.156] | 0.228 | |||
| Tumor stage III–IV |
1.558 [0.898–2.704] | 0.115 | |||
| T stage T3–4 |
1.607 [0.977–2.643] | 0.062 | |||
| Primary therapy outcome Complete remission |
0.282 [0.176–0.453] | <0.001 | (+) | 0.242 [0.147–0.397] | <0.001 |
| Lymphovascular invasion Yes |
2.109 [1.266–3.512] | 0.004 | (+) | 1.690 [0.991–2.881] | 0.054 |
| Perineural invasion Yes |
1.727 [1.081–2.759] | 0.022 | (+) | 1.475 [0.857–2.538] | 0.161 |
| N stage Non N0 |
1.833 [1.131–2.971] | 0.014 | (+) | 1.250 [0.711–2.194] | 0.438 |
Note:
T, primary tumor; N, regional lymph nodes; (+), selected by LASSO regression. The bold characters refers to the P-values of indicators that were statistically significant in the regression models.