Table 4.

Summary of point mutations and amino acid changes in VEEV TC83 that emerged at various concentrations of BDGR-4

Nucleotide Change	Amino Acid Change	Gene	Replicate	50 nM	100 nM	200 nM	400 nM	800 nM	1600 nM	3200 nM
G3033A	E452K	nsP2	R1	-	-	-	-	-	-	21.4
			R1	-	-	-	30.51	31.43	64.53	73.86
G5414A	A461A	nsP3	R2	-	-	7.15	27.91	27.26	45.33	56.89
			R3	-	-	2.63	15.85	21.07	35.91	42.91
			R1	-	-	3.34	31.17	37.73	62.04	72.66
A5962T	Y87F	nsP4	R2	-	-	8.37	26.95	-	45.58	62.36
			R3	-	-	2.95	19.91	26.23	38.7	53.9
C6330A	Q210K	nsP4	R2	-	-	-	-	-	-	10.07
			R1	-	-	-	-	-	66.8	79.01
A6331G	Q210R	nsP4	R2	-	-	-	-	-	-	67.65
			R3	-	-	-	-	-	-	61.86
			R1	-	-	1.96	21.62	23.81	17.14	7.58
A6332T	Q210H	nsP4	R2	-	-	-	27.89	-	-	-
			R3	-	-	2.77	19.8	26.01	-	-
A6341T	E213D	nsP4	R2	-	-	-	10.74	-	4.21	-
			R3	-	-	0.65	4.34	4.06	1.67	-
			R1	-	-	2.52	28.32	37.32	57.49	66.97
G6617A	R305R	nsP4	R2	-	-	5.66	19.26	23.88	36.21	50.47
			R3	-	-	1.87	15.21	22.36	33.4	48.06
G10639A	L213L	E1	R2	-	-	1.53	-	-	-	12.43
			R3	-	-	-	-	5.97	10.71	-