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. 2020 Jun 12;13:5563–5574. doi: 10.2147/OTT.S249429

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© 2020 Chen et al.

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Relationship of regulation between SNHG12 and miR-195. (A) Predicted binding site of miR-195 in SNHG12 using starBase v2.0. (B) RNA immunoprecipitation (RIP) experiments for SNHG12 and miR-195 in OCI-LY7 and OCI-LY3 cell lines. (C) Relative expression of miR-195 was verified in DLBCL (n = 80) tissues compared to control lymphoid hyperplasia tissues (n = 80) by quantitative real-time PCR. (D) Pearson correlation analysis between SNHG12 and miR-195 expression levels in DLBCL tissues. (E) Relative expression of miR-195 was verified in DLBCL cell lines. (F) Luciferase reporter plasmid containing wild-type (WT) SNHG12 or mutant (MUT) SNHG12 were co-transfected into in OCI-LY7 and OCI-LY3 cell lines with miR-195 mimics or mimics control. (G) Relative expression of miR-195 was verified in OCI-LY7 and OCI-LY3 cells after knockdown or overexpression of SNHG12. Data are presented as mean ± SD of three independent experiments. ***P < 0.001. ns, not significant.

Abbreviation: DLBCL, diffuse large B-cell lymphoma.