Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 20;218:108516. doi: 10.1016/j.clim.2020.108516

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 3 — The cytotoxic potential of CD8⁺ T cells and NK cells in COVID-19 patients. (A) CD8⁺ T cells in COVID-19 patients had higher expression of cytotoxic granules (GrA, GrB and perforin) compared to HCs. And the expression of GrA and perforin on NK cells in COVID-19 patients was also significantly increased while GrB expression was decreased compared to HCs. (B) There are slight differences in the expression of perforin and granzyme in COVID-19 patients of different severity. The expression of GrB and perforin on CD8⁺ T cells in the Critical group was significantly increased as compared with the Severe or Mild group; the expression of GrA on NK cells in the Mild and Severe groups was significantly increased as compared with HCs and the Critical group; the expression of perforin on NK cells in the Severe group was significantly increased as compared with the Mild group. The expression of GrA on CD8⁺ T cells and GrB on NK cells was not significantly different among different severity of the disease.