Table 2:

Main effect and interaction effects for polygenic risk scores (PRS) associated with MDD overall and in stratified analyses. Interaction effects are on the additive scale (Beta) and the multiplicative scale (OR). Bold = significant associations (main analyses: p < 0.000143; interactions: p < 0.01). Base N = Cases // Controls. OR/Beta = Increase with 1 SD increase in risk score or trauma exposure. Results are reported at the “best” threshold (that with the lowest p-value in main effect analyses) - results across all thresholds are reported in Supplementary Table 10.

Base	Base N	Best Threshold	Analysis	PRS			PRS x Reported Trauma
							Additive			Multiplicative
				OR	95% CI	p	Beta	95% CI	p	OR	95% CI	p
MDD	116,404 // 314,990	0.5	MDD	1.26	1.24-1.28	< 10−50	0.011	0.008-0.014	2.69x10−11	1.01	1.00 - 1.03	0.132
SCZ	36,989 // 113,075	0.3		1.11	1.09-1.12	1.11 x 10−41	0.008	−0.003-0.004	0.659	0.99	0.97-1.00	0.158
BIP	7,481 // 9,250	0.2		1.07	1.05-1.08	4.57 x 10−19	−0.000	−0.003-0.003	0.961	0.99	0.97-1.00	0.165
BMI	339,224	0.3		1.04	1.03-1.06	2.60 x 10−8	0.006	0.003-0.009	1.13x10−4	1.02	1.01-1.04	0.0074
HB1Ac	46,368	0.001		1.01	1.00-1.02	0.163	0.002	−0.001-0.005	0.186	1.01	0.99-1.02	0.391
MDD	116,404 // 314,990	0.4	MDD, reported trauma exposure	1.24	1.21-1.27	< 10−50
SCZ	36,989 // 113,075	0.5		1.06	1.03-1.09	2.96 x 10−5
BIP	7,481 // 9,250	0.5		1.04	1.01-1.07	0.00329
BMI	339,224	0.5		1.07	1.04-1.10	1.85 x 10−7
HB1Ac	46,368	0.001		1.02	1.00-1.05	0.0863
MDD	116,404 // 314,990	0.4	MDD, no reported trauma exposure	1.21	1.18-1.23	< 10−50
SCZ	36,989 // 113,075	0.5		1.09	1.06-1.11	4.34 x 10−12
BIP	7,481 // 9,250	0.2		1.07	1.04-1.09	4.05 x 10−8
BMI	339,224	0.3		1.02	1.00-1.04	0.0980
HB1Ac	46,368	0.001		1.01	0.99-1.03	0.492