Table 2:
Main effect and interaction effects for polygenic risk scores (PRS) associated with MDD overall and in stratified analyses. Interaction effects are on the additive scale (Beta) and the multiplicative scale (OR). Bold = significant associations (main analyses: p < 0.000143; interactions: p < 0.01). Base N = Cases // Controls. OR/Beta = Increase with 1 SD increase in risk score or trauma exposure. Results are reported at the “best” threshold (that with the lowest p-value in main effect analyses) - results across all thresholds are reported in Supplementary Table 10.
Base | Base N | Best Threshold | Analysis | PRS | PRS x Reported Trauma | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Additive | Multiplicative | |||||||||||
OR | 95% CI | p | Beta | 95% CI | p | OR | 95% CI | p | ||||
MDD | 116,404 // 314,990 | 0.5 | MDD | 1.26 | 1.24-1.28 | < 10−50 | 0.011 | 0.008-0.014 | 2.69x10−11 | 1.01 | 1.00 - 1.03 | 0.132 |
SCZ | 36,989 // 113,075 | 0.3 | 1.11 | 1.09-1.12 | 1.11 x 10−41 | 0.008 | −0.003-0.004 | 0.659 | 0.99 | 0.97-1.00 | 0.158 | |
BIP | 7,481 // 9,250 | 0.2 | 1.07 | 1.05-1.08 | 4.57 x 10−19 | −0.000 | −0.003-0.003 | 0.961 | 0.99 | 0.97-1.00 | 0.165 | |
BMI | 339,224 | 0.3 | 1.04 | 1.03-1.06 | 2.60 x 10−8 | 0.006 | 0.003-0.009 | 1.13x10−4 | 1.02 | 1.01-1.04 | 0.0074 | |
HB1Ac | 46,368 | 0.001 | 1.01 | 1.00-1.02 | 0.163 | 0.002 | −0.001-0.005 | 0.186 | 1.01 | 0.99-1.02 | 0.391 | |
MDD | 116,404 // 314,990 | 0.4 | MDD, reported trauma exposure | 1.24 | 1.21-1.27 | < 10−50 | ||||||
SCZ | 36,989 // 113,075 | 0.5 | 1.06 | 1.03-1.09 | 2.96 x 10−5 | |||||||
BIP | 7,481 // 9,250 | 0.5 | 1.04 | 1.01-1.07 | 0.00329 | |||||||
BMI | 339,224 | 0.5 | 1.07 | 1.04-1.10 | 1.85 x 10−7 | |||||||
HB1Ac | 46,368 | 0.001 | 1.02 | 1.00-1.05 | 0.0863 | |||||||
MDD | 116,404 // 314,990 | 0.4 | MDD, no reported trauma exposure | 1.21 | 1.18-1.23 | < 10−50 | ||||||
SCZ | 36,989 // 113,075 | 0.5 | 1.09 | 1.06-1.11 | 4.34 x 10−12 | |||||||
BIP | 7,481 // 9,250 | 0.2 | 1.07 | 1.04-1.09 | 4.05 x 10−8 | |||||||
BMI | 339,224 | 0.3 | 1.02 | 1.00-1.04 | 0.0980 | |||||||
HB1Ac | 46,368 | 0.001 | 1.01 | 0.99-1.03 | 0.492 |