Table 4.
PDB holdings for antineoplastic biologic-NMEs approved 2010–2018
| Types of biologic-NMEs | Number of biologic-NMEs of each type | Number of biologic-NMEs with PDB target structure(s) | Unique PDB IDs for biologic-NME target structures (95% identity) | Biologic-NME structure(s) in PDB |
|---|---|---|---|---|
| Antibodies | 16 | 14 (~88%) | 395 | 8 (50%) |
| ADCs | 4 | 4 (100%) | 30 | 1 (25%) |
| Othera | 5 | 2 (40%) | 48 | 4 (80%) |
| All | 25 | 20 (80%) | 405 | 13 (52%) |
a
Other: calaspargase pegol-mknl, asparaginase Erwinia chrysanthemi, ziv-aflibercept, tagraxofusp-erzs, lutetium Lu 177 dotatate.