Figure 1:

Dietary compositions affect circulating metabolic factors and nutrient availability which, in turn, are thought to have effects on tumor cell metabolism. Dietary timing as well as caloric compositions are known to affect endocrine secretions of insulin which thereby affect cellular uptake of glucose. Limitations of glucose and an abundance of ketone bodies during the ketosis induced by the ketogenic diet has been linked to reduced glycolysis and enhanced oxidative processing. These suggest that, while these mechanisms are not well understood, diets may have important roles in driving cancer cell metabolism.