Table 2.
Altered lncRNAs in Parkinson' Disease.
| Tissue | Ethnicity/population | LncRNA | Regulation | References |
|---|---|---|---|---|
| Substantia nigra and cerebellum (9 patients with PD and 8 controls) | Not mentioned (the tissue were obtained from The Netherlands brain Bank) | AK127687, AX747125, GBAP1, SNCA-AS1, UCHL1-AS1, PINK1-AS1, and MAPT-AS1 | Up | [47] |
| Anterior cingulate gyrus (20 patients with PD and 10 controls) | Not mentioned (the tissue were provided by the Neurobiobank Munich (NBM)) | H19 upstream conserved 1 and 2 | Up | [48] |
| LincRNA-p21, MALAT1, SNHG1, and TncRNA | Down | |||
| Exosomes isolated from CSF (47 patients with PD and 27 controls) | Not mentioned (the tissue were provided by the sir Run Run shaw hospital, affiliated with school of medicine, Zhejiang University) | RP11-462G22.1 and PCA3 | Up | [49] |
| Extracellular RNAs present in CSF (27 patients with PD and 30 controls) | Not mentioned (the tissue were provided by the hospital Universitario Donostia, San Sebastian, Spain (MDUD)) | AC079630 and UC001lva.4 (close to the LRRK2 gene locus) | Up | [50] |
| Substantia nigra (11 patients with PD and 14 controls) | Not mentioned (the volunteers who provided the tissue were from USA, UK, Israel, and Germany) | AL049437, U79277, AF052141, AK021454, BC018626, AF147723, AK001884, AY365119, BC151247, BC151234, AK311445, AK310272, AK094351, AF007131, AF119861, CR619166, AK023852, AK074162, AF052176, BC007937, AK025388, AK022431, CR618512, AK021912, AL109681, AF090884, AL359578, AF070543, AK021798, AK024568, U94902, AK024381, AF090910, BC002644, BC064478, AF007141, M28219, AK001998, BC002821, AL049328, AK024684, and AK000420 | Up | [51] |
| AK024198, AK025097, AK024214, AF052148, AF070579, AK023918, AK022167, AK024938, AL109707, BC000988, AK025271, AL109705, AJ001873, BC029383, AK025360, | Down | |||
| Blood leukocytes sample (3 patients with PD) | Not mentioned | RP11-101C11.1, U1∗‘#, RP11-425i13.3, RP11-124n14.3, RP11-79p5.3, RP11-462g22.1, RP13-507P19.2, and PCA3 | Up | [20] |
| RP11-409K20.6, RP4-705O1.1, AC004744.3, RP11-533O20.2, and RP11-542K23.9 | Down | |||
| Brain tissue samples (10 patients with PD and 10 controls) | Caucasian descent (the tissue were provided by the Sydney Brain Bank and the NSW Tissue Resource Centre) | MAPT-AS1 | Down | [35] |
| Plasma samples (32 patients with PD and 13 controls) | Not mentioned (the volunteers who provided the tissue were from Beijing Tiantan Hospital) | MSTRG.242001.1, MSTRG.169261.1 | Up | [52] |
| MSTRG.336210.1, lnc-MKRN2-42 : 1 | Down | |||
| Substantia nigra from mice (3 Nrf2+/+ mice and 3 Nrf2-/- mice) | AK020441, AK020330, NR_003555, NR_073442, AK040987, ENSMUST00000142871, ENSMUST00000153819, ENSMUST00000132304, uc011ysu.1, and so forth (a total of 74) | Up | [53] | |
| ENSMUST00000139383, NR_024325, AK047372, ENSMUST00000156693, ENSMUST00000181307, AK076880, AK036620, TCONS_00017218, TCONS_00022981, TCONS_00004085, and so forth (a total of 160) | Down | |||
| Whole mesencephalic tissues from mice (6 α-synuclein transgenic C57BL/6 mice and 6 control mice) | uc.44-, BC037523, and so forth (a total of 164) | Up | [54] | |
| uc.12+, AK076860, and so forth (a total of 177) | Down | |||
| The striatum from rat (9 PD model and 9 control rats) | XLOC_026924, XLOC_029397, XLOC_004631, XLOC_005439, XLOC_018657, XLOC_016191, XLOC_022926, AABR07029901.1, XLOC_025867, XLOC_016202, and so forth (a total of 451) | Up | [55] | |
| XLOC_028318, XLOC_037769, XLOC_029657, XLOC_010572, XLOC_017775, XLOC_018598, Rn50_5_1638.1, XLOC_006399, AABR07027137.1, XLOC_001547, and so forth (a total of 61) | Down | |||
| SY-SH5Y cells treated with a-synuclein oligomers | A total of 53 lncRNAs | Up | [56] | |
| A total of 69 lncRNAs | Down | |||
| Whole mesencephalic tissues from mice (6 α-synuclein transgenic C57BL/6 mice and 6 control mice) | uc.44-, BC037523, and so forth (a total of 164) | Up | [5] | |
| uc.12+, AK076860, and so forth (a total of 177) | Down |