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. 2020 Jun 20;17:196. doi: 10.1186/s12974-020-01867-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Frequencies of NLRP3-, MEFV-, and TNFRSF1 low-penetrance variants. All patients had sequence variants in NLRP3 (exon 3, 4, 6), MEFV (exon 2, 3, 10), and/or TNFRSF1A (exon 2, 3, 4, 6) gene and were categorized due to their underlying mutation and their MS status (AID w/o or with MS). Pie charts demonstrate absolute numbers of mutations. a Red slices represent NLRP3 variants. b Green slices show different MEFV variants, while c TNFRSF1A variants are symbolized by blue charts. Homozygous variants are marked as +/+, heterozygous variants are labeled by +/− symbols