Fig. 1.

Patients with mitochondrial disease experience chronic pain. (A) Number of female (light grey) and male (dark grey) respondents according to age. P = 0.51 for the age distribution of female and male respondents (t-test). (B) Number of female and male respondents who reported chronic pain (i.e., long-term pain other than minor headaches, sprains and toothaches, in the last six months). (C) Age at which respondents first experienced chronic pain versus current age. Dashed line is where age of onset is same as current age. (D–G) Average, current, worst and best pain intensities are significantly higher among those respondents who reported chronic pain (Wilcoxon test).