Fig. 10.

a,b: Bar graphs displaying novel object recognition (NOR) task results. a. Comparison of D2 ratios between 4 and 12 months old. The control mice had an increasing D2 ratio between 4 and 12 months old demonstrating an increased preference for the novel object. The mdx mice showed an increased preference for the familiar object at all-time points; however, the D2 ratio increased over time as the mice spent less time exploring the object in total. b. Bar graph displaying the amount of time that mice spent in the corners of the NOR arena between 4 and 12 months old. The control mice spent considerably less time in the corners during both the sample and choice phase compared to the mdx mice. At 4, 6 and 12 months old the mdx mice spent significantly longer in the corners during the sample and choice phases of NOR and this time increased with increasing age compared to control mice (p < 0.05). Data presented as mean ± SEM, *p < 0.05, **p < 0.01 for control vs. mdx, ^p < 0.05, ^^p < 0.01 for changes observed with ageing in mdx mice, $<p.0.05 for changes observed with ageing in control mice.