Table 4.
Effect of tranexamic acid on the need for surgical, endoscopic, and radiological interventions or blood product transfusion
| Tranexamic acid | Placebo | Outcomes | |
|---|---|---|---|
| Interventions | |||
| Diagnostic endoscopy | 4781/5953 (80·3%) | 4729/5978 (79·1%) | 1·02 (1·00 to 1·03) |
| Therapeutic endoscopy | 2542/5952 (42·7%) | 2658/5978 (44.5%) | 0·96 (0·92 to 1·00) |
| Diagnostic radiological procedure | 1704/5953 (28·6%) | 1744/5978 (29·2%) | 0·98 (0·93 to 1·04) |
| Therapeutic radiological procedure | 74/5953 (1·2%) | 89/5978(1·5%) | 0·83 (0·61 to 1·13) |
| Surgical intervention | 146/5953 (2·5%) | 158/5978 (2·6%) | 0·93 (0·74 to 1·16) |
| Any surgical, endoscopic, or radiological intervention | 5216/5956 (87·6%) | 5236/5981 (87·5%) | 1·00 (0·99 to 1·01) |
| Any transfusion | 4076/5951 (68·5%) | 4129/5978 (69·1%) | 0·99 (0·97 to 1·02) |
| Whole blood or red cells | 3984/4076 (97·7%) | 4018/4129 (97·3%) | 1·00 (1·00 to 1·01) |
| Frozen plasma | 910/4076 (22·3%) | 993/4129 (24·0%) | 0·93 (0·86 to 1·00) |
| Any platelets | 219/4076 (5·4%) | 255/4129 (6·2%) | 0·87 (0·73 to 1·04) |
| Blood product transfusions | |||
| Units of whole blood or red cells | 2·8 (2·4) | 2·9 (2·7) | −0·06 (0·05 to −0·18) |
| Units of frozen plasma | 0·9 (2·4) | 1·0 (2·6) | −0·05 (−0·01 to −0·23) |
| Units of any platelets | 0·2 (0·9) | 0·2 (1·0) | −0·02 (0·02 to −0·06) |
Data for interventions are n/N (%) and risk ratio (95% CI); data for blood product transfusions are mean (SD) and difference in means (95% CI).