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Five-year absolute risks of site-specific cancers by PRS groups. Five-year absolute risk of developing cancer of (A) prostate, (B) breast, (C) colorectal, (D) and lung. The horizontal lines show the estimated 5-year risk for individuals with median PRS (45%-55%) at the age of 50 years for (B) breast cancer or (C) colorectal cancer. PRS = polygenic risk score.
