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. 2020 Jun 21;98:166–175. doi: 10.1016/j.ijid.2020.06.063

Table 2.

FDA-approved drug showing high binding affinities against protease and RBD of SARS-CoV-2.

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Drug name Formula DrugBank ID Glide score Drug name Formula DrugBank ID Glide score
Acarbose C25H43NO18 DB00284 −13.139 Framycetin C23H46N6O13 DB00452 −11.233
Colistin C52H98N16O13 DB00803 −12.63 Acarbose C25H43NO18 DB00284 −10.649
Paromomycin C23H45N5O14 DB01421 −11.579 Paromomycin C23H45N5O14 DB01421 −10.01
Iotrolan C37H48I6N6O18 DB09487 −11.001 Plazomicin C25H48N6O10 DB12615 −9.935
Indium In-111 pentetreotide C62H80InN12O19S2 DB11835 −10.795 Omadacycline C29H40N4O7 DB12455 −9.178
Framycetin C23H46N6O13 DB00452 −10.713 Mangafodipir C22H30MnN4O14P2 DB06796 −9.089
Lutetium Lu-177 dotatate C65H87LuN14O19S2 DB13985 −10.607 Flavin adenine dinucleotide C27H33N9O15P2 DB03147 −8.986
Rutin C27H30O16 DB01698 −9.853 Ribostamycin C17H34N4O10 DB03615 −8.781

FDA, US Food and Drug Administration; RBD, receptor-binding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.