Table 2.
Cytotoxic activity of N-heteroaryl enamino amides and dihydropyrimidinethiones assessed by the MTT reduction assay. Data are presented as mean ± SEM, n = 3.
 | |||
|---|---|---|---|
| Compounds | R | IC50 (μM) | |
| AGS cells | MCF-7 cells | ||
| 1a | 5-Methyl isoxazol-3-yl | 2196.40 ± 36.32 | 2367.91 ± 41.26 |
| 2a | 2-Thiazolyl | 453.14 ± 14.29 | 761.90 ± 20.14 |
| 3a | 6-Methoxy benzothiazole-2-yl | 1946.01 ± 49.52 | 2375.28 ± 33.21 |
| 4a | 4-Methyl benzothiazole-2-yl | 1291.58 ± 28.39 | 1429.92 ± 46.99 |
| 5a | 6-Methyl benzothiazole-2-yl | 1468.21 ± 19.32 | 1659.40 ± 17.26 |
| 6a | 4-(4-Bromophenyl) thiazole-2-yl | 617.62 ± 22.62 | 487.20 ± 28.43 |
| 7a | Phenyl | 2223.92 ± 64.16 | 2451.45 ± 39.82 |
| 1b | Phenyl | 98.48 ± 10.62 | 149.13 ± 9.01 |
| 2b | 4-methylbenzothiazol-2-yl | 41.10 ± 5.01 | 75.69 ± 7.87 |
| Cis-platin | - | 11.49 ± 0.90 | 6.02 ± 2.29 |