Table 1.
The most negative ΔΔGs of suggested mutations using PoPMuSiC and Eris servers.
| Mutations | POPmusic ΔΔG (Kcal/mol) |
Eris energy (Kcal/mol) |
Scorea |
|---|---|---|---|
| Q74I | -2.22 | -9.6 | ++ |
| Q74V | -1.98 | -6.83 | ++ |
| Q74F | -1.82 | 9.01 | + |
| N23I | -1.68 | 2.36 | + |
| Q74L | -1.52 | -5.01 | ++ |
| Q74W | -1.52 | 9.74 | + |
| Q74Y | -1.46 | 4.39 | + |
| N23V | -1.45 | 5.55 | + |
| S153I | -1.43 | 0.8 | + |
| S153V | -1.39 | -2.0 | ++ |
| N23F | -1.32 | -2.26 | ++ |
| N23L | -1.18 | -3.88 | ++ |
| Q74C | -1.1 | 1.28 | + |
| N23Y | -1.06 | 0.72 | + |
| N23C | -1.01 | 3.39 | + |
a, The mutations that had good score energetically in terms of both servers indicated with double plus and the other mutations with one plus approved by Pop music server only.