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Bicarbonate-dependence of K+-induced alkalinization. pHi records on the left were obtained in HEPES-buffered perfusate. The records on the right were obtained in the same preparation (but different cells) following substitution of HCO3− -buffered perfusate. In both astrocytes and Müller cells, application of 12 mM K+ induces a larger alkalinization in the presence of HCO3−.
