Table 1:
Comparison of preoperative characteristics, operative variables and post-operative outcomes of patients stratified by dual antiplatelet utilization.
| No DAPT | DAPT | p-value | |
|---|---|---|---|
| n | 5029 (68.8%) | 2285 (31.2%) | |
| Preoperative Characteristics | |||
| Age | 64.4 ± 10.6 | 63 ± 10.7 | <0.0001 |
| Sex (Female) | 1335 (26.9%) | 669 (29.3%) | 0.0386 |
| Hypertension | 4258 (84.8%) | 2006 (87.9%) | 0.0005 |
| Diabetes Mellitus | 2428 (48.3%) | 1139 (49.9%) | 0.2184 |
| Peripheral Arterial Disease | 640 (12.8%) | 399 (17.5%) | <0.0001 |
| History of Atrial Fibrillation | 284 (12.4%) | 97 (8.2%) | 0.0002 |
| History of Heart Failure | 1394 (27.7%) | 586 (25.7%) | 0.0643 |
| History of Cerebrovascular Accident | 411 (8.2%) | 250 (11.0%) | 0.0001 |
| History of PCI | 1175 (23.4%) | 848 (37.1%) | <0.0001 |
| Preoperative Hemodialysis | 189 (3.8%) | 78 (3.4%) | 0.4664 |
| Predicted Risk of Mortality | 1.53% [0.79–3.35] | 1.51% [0.75–3.25] | 0.2863 |
| Presentation and Operative Factors | |||
| ST Segment Elevation Myocardial Infarction | 762 (15.2%) | 412 (18.1%) | 0.0016 |
| ADP inhibitor within 5 days | 829 (16.5%) | 511 (22.4%) | <0.0001 |
| Off-Pump Surgery | 188 (3.7%) | 289 (12.7%) | <0.0001 |
| Cross Clamp Time | 67 [52–84] | 74 [56–94] | <0.0001 |
| Cardiopulmonary Bypass Time | 93 [73–116] | 102 [79–126] | <0.0001 |
| Post-operative Medications | |||
| Aspirin at Discharge | 4878 (97%) | 2285 (100%) | <0.0001 |
| ADP Inhibitor at Discharge | 75 (1.5%) | 2285 (100%) | <0.0001 |
| Discharge Anticoagulant | 754 (15.0%) | 114 (5.0%) | <0.0001 |
| Post-operative Outcomes | |||
| Operative Mortality | 34 (0.7%) | 10 (0.4%) | 0.2216 |
| Major Morbidity | 660 (13.1%) | 218 (9.5%) | <0.0001 |
| Post-operative Atrial Fibrillation | 1192 (23.7%) | 426 (18.7%) | <0.0001 |
| Transfusion | 1552 (30.9%) | 603 (26.4%) | <0.0001 |
| Renal Failure | 120 (2.4%) | 27 (1.2%) | 0.0007 |
| Stroke | 69 (1.4%) | 34 (1.5%) | 0.695 |
| Cardiac Arrest | 68 (1.4%) | 21 (0.9%) | 0.1178 |
| DSWI | 15 (0.3%) | 8 (0.4%) | 0.7129 |
| Reoperation for Bleeding | 101 (2.0%) | 36 (1.6%) | 0.2057 |
| Prolonged Ventilation (>24 Hours) | 460 (9.2%) | 139 (6.1%) | <0.0001 |
| Post-operative Length of Stay | 6 [5–8] | 6 [4–8] | <0.0001 |
| Readmission | 535 (10.6%) | 242 (10.6%) | 0.9513 |
(ADP: Adenosine Diphosphate; DSWI: Deep Sternal Wound Infection; PCI: Percutaneous Coronary Intervention)