Table 1:
Discovery cohort N = 36 | Validation cohort N = 140 | P value | |
---|---|---|---|
Pre-transplant age (years) | 13 (8,16) | 10 (6,14) | 0.7 |
Male gender | 22 (62%) | 83 (59%) | 0.9 |
Primary Disease | <0.001 | ||
Malignancy | 26 (72%) | 38 (27%) | |
Immunodeficiency | 4 (11%) | 33 (23%) | |
Bone marrow failure | 4 (11%) | 65 (46%) | |
Genetic/metabolic | 1 (2 %) | 4 (3%) | |
Benign hematological | 1 (2 %) | 0 (0%) | |
Donor | 0.24 | ||
Unrelated | 26 (72%) | 93 (66.4%) | |
Related | 10 (28%) | 47 (33.6%) | |
Donor Source | <0.001 | ||
Marrow | 10 (28%) | 102 (72%) | |
Peripheral blood | 26 (72%) | 32 (22%) | |
Cord blood | 0 (0%) | 1 (1%) | |
Combined Marrow and Cord | 0 (0%) | 5 (4%) | |
Pre-transplant eGFR (ml/min/1.73m2) | 134 (107,168) | 127 (106,153) | 0.15 |
Myeloablative conditioning | 31 (86%) | 91 (65%) | <0.001 |
Data shown as median (inter quartile range) or n (%); eGFR. Estimated glomerular filtration rate