Table 1.
Antipsychotic drug use during the pregnancy period by country and maternal age.
| Pregnancies with at least 1 filled prescription of: | ||||
|---|---|---|---|---|
| Total number of pregnancies | Any antipsychotic | Typical antipsychotic | Atypical antipsychotic | |
| N | N (%) | N (%) | N (%) | |
| NSW, Australia 2004–2012 | ||||
| All ages | 148,462 | 2,355 (1.59) | 497 (0.33) | 2,020 (1.36) |
| ≤ 24 years | 50,573 | 635 (1.26) | 110 (0.22) | 559 (1.11) |
| 25–34 years | 73,399 | 1,195 (1.63) | 269 (0.37) | 1,017 (1.39) |
| ≥35 years | 24,480 | 523 (2.14) | 119 (0.49) | 443 (1.81) |
| Denmark 2000–2012 | ||||
| All ages | 813,360 | 2,858 (0.35) | 1,844 (0.23) | 1,269 (0.16) |
| ≤24 years | 87,014 | 458 (0.53) | 307 (0.35) | 211 (0.24) |
| 25–34 years | 485,356 | 1,240 (0.26) | 864 (0.18) | 487 (0.10) |
| ≥35 years | 125,804 | 565 (0.45) | 382 (0.30) | 218 (0.17) |
| Finland 2005–2014 | ||||
| All ages | 584,139 | 4,374 (0.75) | 977 (0.17) | 3,741 (0.64) |
| ≤24 years | 103,690 | 1,114 (1.07) | 166 (0.16) | 1,014 (0.98) |
| 25–34 years | 370,232 | 2,372 (0.64) | 549 (0.15) | 2,021 (0.55) |
| ≥35 years | 110,217 | 888 (0.81) | 262 (0.24) | 706 (0.64) |
| Germany 2006–2015 | ||||
| All ages | 999,105 | 2,842 (0.28) | 1,193 (0.12) | 1,912 (0.19) |
| ≤24 years | 80,050 | 369 (0.46) | 165 (0.21) | 241 (0.30) |
| 25–34 years | 616,444 | 1,442 (0.23) | 613 (0.10) | 960 (0.16) |
| ≥35 years | 302,611 | 1,031 (0.34) | 415 (0.14) | 711 (0.23) |
| Hong Kong 2001–2015 | ||||
| All ages | 416,494 | 1,408 (0.34) | 910 (0.22) | 705 (0.17) |
| ≤24 years | 43,205 | 187 (0.43) | 113 (0.26) | 110 (0.25) |
| 25–34 years | 269,014 | 744 (0.28) | 490 (0.18) | 357 (0.13) |
| ≥35 years | 104,274 | 477 (0.46) | 307 (0.29) | 238 (0.23) |
| Iceland 2004–2017 | ||||
| All ages | 60,477 | 881 (1.46) | 504 (0.83) | 435 (0.55) |
| ≤ 24 years | 10,738 | 239 (2.23) | 110 (1.02) | 145 (1.05) |
| 25–34 years | 37,237 | 487 (1.31) | 304 (0.82) | 216 (0.41) |
| ≥35 years | 12,502 | 155 (1.24) | 90 (0.72) | 32 (0.41) |
| Norway 2005–2015 | ||||
| All ages | 645,459 | 7,492 (1.16) | 6,162 (0.95) | 1,539 (0.24) |
| ≤ 24 years | 103,305 | 1,560 (1.51) | 1,236 (1.20) | 378 (0.37) |
| 25–34 years | 418,034 | 4,472 (1.07) | 3,772 (0.90) | 809 (0.19) |
| ≥35 years | 124,120 | 1,460 (1.18) | 1,154 (0.93) | 352 (0.28) |
| Sweden 2006–2015 | ||||
| All ages | 1,028,732 | 3,929 (0.38) | 2,079 (0.20) | 2,097 (0.20) |
| ≤ 24 years | 148,042 | 731 (0.49) | 367 (0.25) | 423 (0.29) |
| 25–34 years | 654,477 | 2,249 (0.34) | 1,243 (0.19) | 1,136 (0.17) |
| ≥35 years | 226,190 | 949 (0.42) | 538 (0.24) | 469 (0.21) |
| UK 2006–2016 | ||||
| All ages | 767,251 | 35,577 (4.64) | 33,884 (4.42) | 2,115 (0.28) |
| ≤ 24 years | 232,391 | 8,427 (3.63) | 8,093 (3.48) | 431 (0.19) |
| 25–34 years | 374,185 | 20,053 (5.36) | 19,187 (5.13) | 1,096 (0.29) |
| ≥35 years | 160,675 | 7,097 (4.42) | 6,604 (4.11) | 588 (0.37) |
| US, MarketScan 2012–2015 | ||||
| All ages | 859,505 | 6,761 (0.79) | 3,371 (0.39) | 3,514 (0.41) |
| ≤ 24 years | 134,218 | 1,905 (1.42) | 688 (0.51) | 1,261 (0.94) |
| 25–34 years | 532,887 | 3,485 (0.65) | 2,007 (0.38) | 1,534 (0.29) |
| ≥35 years | 192,400 | 1,371 (0.71) | 676 (0.35) | 719 (0.37) |
| US, MAX 2000–2013 | ||||
| All ages | 2,071,359 | 66,820 (3.23) | 37,200 (1.80) | 31,712 (1.53) |
| ≤ 24 years | 1,180,493 | 34,530 (2.93) | 19,626 (1.66) | 15,741 (1.33) |
| 25–34 years | 752,111 | 27,241 (3.62) | 15,151 (2.01) | 13,109 (1.74) |
| ≥35 years | 138,755 | 5,049 (3.64) | 2,423 (1.75) | 2,862 (2.06) |
Note: The pregnancy period is defined as 90 days before the date of the last menstrual period to the date of birth.