Table 3.
Pooled prevalence of antipsychotic drug use during the pregnancy period in the Nordic countries by maternal and pregnancy characteristics.
| Any antipsychotic | Typical antipsychotic | Atypical antipsychotic | |||||
|---|---|---|---|---|---|---|---|
| Country (weight %) | Total | N | Prevalence (95% CI)a | N | Prevalence (95% CI)a | N | Prevalence (95% CI)a |
| Pooled (100) | 3,132,167 | 19,534 | 0.58 (0.58, 0.59) | 11,566 | 0.32 (0.31, 0.33) | 9,081 | 0.27 (0.26, 0.27) |
| Denmark (26.0) | 813,360 | 2,858 | 0.35 (0.34, 0.36) | 1,844 | 0.23 (0.22, 0.24) | 1,269 | 0.16 (0.15, 0.16) |
| Iceland (1.9) | 60,477 | 881 | 1.46 (1.36, 1.55) | 504 | 0.83 (0.76, 0.91) | 435 | 0.72 (0.65, 0.79) |
| Finland (18.7) | 584,139 | 4,374 | 0.75 (0.73, 0.77) | 977 | 0.17 (0.16, 0.18) | 3,741 | 0.64 (0.62, 0.66) |
| Norway (20.6) | 645,459 | 7,492 | 1.16 (1.13, 1.19) | 6,162 | 0.95 (0.93, 0.98) | 1,539 | 0.24 (0.23, 0.25) |
| Sweden (32.8) | 1,028,732 | 3,929 | 0.38 (0.37, 0.39) | 2,079 | 0.20 (0.19, 0.21) | 2,097 | 0.20 (0.20, 0.21) |
| Parity | |||||||
| 1 | 1,299,079 | 7,580 | 0.55 (0.54, 0.56) | 4,497 | 0.30 (0.29, 0.31) | 3,583 | 0.27 (0.26, 0.28) |
| 2 | 1,004,582 | 5,177 | 0.47 (0.45, 0.48) | 3,600 | 0.34 (0.33, 0.35) | 1,782 | 0.16 (0.16, 0.17) |
| 3 | 381,385 | 2,553 | 0.62 (0.60, 0.65) | 1,781 | 0.41 (0.39, 0.43) | 895 | 0.22 (0.21, 0.24) |
| ≥4 | 169,324 | 1,604 | 0.92 (0.87, 0.96) | 1,053 | 0.57 (0.53, 0.60) | 658 | 0.38 (0.36, 0.41) |
| missing | 277,797 | 2,620 | 0.93 (0.90, 0.97) | 635 | 0.21 (0.19, 0.23) | 2,163 | 0.21 (0.19, 0.23) |
| Smokingb | |||||||
| No | 2,551,171 | 11,892 | 0.43 (0.42, 0.44) | 7,411 | 0.24 (0.24, 0.25) | 4,953 | 0.18 (0.18, 0.19) |
| Yes | 341,726 | 5,123 | 1.46 (1.42, 1.50) | 2,448 | 0.68 (0.65, 0.71) | 3,198 | 0.86 (0.83, 0.89) |
| Missing | 178,793 | 1,638 | 0.88 (0.84, 0.92) | 1,203 | 0.62 (0.58, 0.65) | 495 | 0.27 (0.24, 0.29) |
| Cohabitationb | |||||||
| Cohabiting | 1,876,289 | 8,653 | 0.49 (0.48, 0.50) | 3,930 | 0.20 (0.20, 0.21) | 5,368 | 0.33 (0.32, 0.34) |
| Not cohabiting | 516,888 | 2,721 | 0.50 (0.48, 0.52) | 1,172 | 0.39 (0.38, 0.41) | 1,750 | 0.65 (0.63, 0.66) |
| Missing | 93,531 | 668 | 0.70 (0.65, 0.75) | 302 | 0.36 (0.32, 0.39) | 424 | 1.06 (1.03, 1.08) |
| Multi-fetal Pregnancy | |||||||
| No | 3,077,982 | 19,231 | 0.58 (0.58, 0.59) | 11,392 | 0.34 (0.33, 0.35) | 8,939 | 0.27 (0.26, 0.27) |
| Yes | 53,052 | 302 | 0.54 (0.48, 0.60) | 174 | 0.31 (0.26, 0.36) | 142 | 0.23 (0.19, 0.27) |
| Year of Birth | |||||||
| 2000–2004d | 323,511 | 852 | 0.26 (0.24, 0.27) | 712 | 0.21 (0.20, 0.23) | 179 | 0.23 (0.19, 0.27) |
| 2005–2009 | 1,285,897 | 8,695 | 0.64 (0.62, 0.65) | 6,457 | 0.44 (0.43, 0.45) | 2,730 | 0.20 (0.20, 0.21) |
| 2010–2017 | 1,522,759 | 9,987 | 0.61 (0.59, 0.62) | 4,397 | 0.23 (0.22, 0.24) | 6,172 | 0.37 (0.36, 0.38) |
Note: The pregnancy period is defined as 90 days before the date of the last menstrual period to the date of birth.
a
Prevalence per 100 pregnancies weighted by population and 95% confidence intervals (CI)
b
Data on smoking available for Denmark, Finland, Norway, Sweden; Data on cohabitation available for Denmark, Iceland, Finland, Sweden; For Denmark ‘Cohabiting’ reflects marital status
c
Only Denmark and Iceland included births occurring in 2000–2004