Table 3. Absorption and distribution properties of ISL-1 to ISL-18 and ISL.

Comp.	Absorption				Distribution
	Human intestinal absorption (HIA %)	CaCo-2 cell permeability (nm/s)	MDCK cell permeability (nm/s)	Skin permeability (log kp, cm/h)	Plasma protein binding (%)	Blood–brain barrier penetration (c.brain/c.blood)
ISL	88.30	20.15	21.54	–3.28	98.25	1.13
ISL-1	95.82	29.44	163.15	−2.37	97.32	1.52
ISL-2	95.92	31.59	135.64	−2.29	97.84	3.39
ISL-3	95.82	28.15	56.86	−2.60	98.29	1.94
ISL-4	96.56	28.42	0.78	−2.34	100.00	3.54
ISL-5	93.43	19.65	16.63	−2.97	96.44	0.41
ISL-6	95.82	30.28	13.62	−2.60	98.08	2.63
ISL-7	93.43	19.84	27.84	−2.98	97.28	0.32
ISL-8	95.92	31.55	72.27	−2.27	98.20	2.80
ISL-9	95.93	24.94	0.10	−1.51	93.50	5.13
ISL-10	95.79	20.66	51.70	−2.64	92.61	0.09
ISL-11	95.42	33.76	32.53	−2.60	93.71	0.74
ISL-12	95.83	42.02	22.39	−2.64	91.98	1.92
ISL-13	96.65	30.05	60.54	−2.43	100.00	6.39
ISL-14	92.56	16.28	3.22	−2.90	98.80	1.77
ISL-15	94.83	16.99	0.09	−2.90	91.68	1.62
ISL-16	95.98	39.81	0.10	−2.89	90.21	0.06
ISL-17	95.98	39.03	0.05	−2.92	90.88	0.07
ISL-18	96.66	31.47	47.11	−2.31	99.41	3.21

Results were predicted using the server https://preadmet.bmdrc.kr/adme.