Table 4. Metabolism of ISL-1 to ISL-18 and ISL via hepatic microsomal isoforms.

Comp.	CYP_2C19 Inhibition	CYP_2C9 inhibition	CYP_2D6 inhibition	CYP_2D6 substrate	CYP_3A4 inhibition	CYP_3A4 substrate	Pgp_inhibition
ISL	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor
ISL-1	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-2	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-3	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-4	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-5	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor
ISL-6	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-7	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor
ISL-8	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-9	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-10	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-11	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-12	Non-inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-13	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-14	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor	Non-inhibitor	Inhibitor
ISL-15	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor
ISL-16	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor	Weakly	Inhibitor
ISL-17	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor	Weakly	Inhibitor
ISL-18	Inhibitor	Inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Non-inhibitor	Inhibitor

Results were predicted using the server https://preadmet.bmdrc.kr/adme.