FIGURE 1.

Area under the curve (AUC) and optimal amyloid beta (Aβ) thresholds separating cognitively unimpaired elderly and Alzheimer's disease (AD) patients based on voxel‐wise receiver operating characteristic curve (ROC) analysis. A, Voxel‐wise AUC the ROC values separating cognitively unimpaired controls and AD subjects based on Aβ [¹⁸F]florbetapir standardized uptake value ratio (SUVR). Values were the highest in voxels within the precuneus, posterior cingulate, lateral temporal, inferior parietal, and ventromedial prefrontal cortices. B, Voxel‐wise parametric maps showed [¹⁸F]florbetapir SUVR thresholds ranging from 1.15 to 1.71 across the cerebral cortex. The highest SUVR threshold values were found in the precuneus and cingulate cortices, whereas the lowest were located in the medial temporal and occipital cortices