FIGURE 2.

Regional patterns of amyloid beta (Aβ) abnormality differentiate Aβ positive mild cognitive impairment (MCI) progressors from nonprogressors to dementia at individual level. Voxel‐wise maps of Aβ positivity from two representative amnestic Aβ positive MCI individuals: (A) non‐progressor (global [¹⁸F]florbetapir standardized uptake value ratio [SUVR]: 1.42, 73‐year‐old, female, apolipoprotein E [APOE] ε4 positive, Mini‐Mental State Examination [MMSE] = 28) and (B) progressor (global [¹⁸F]florbetapir SUVR = 1.42, 79 year‐old, male, APOE ε4 positive, MMSE = 28). Whereas both individuals demonstrated similar global [¹⁸F]florbetapir SUVR values, the progressor showed more extensive Aβ abnormality in default mode network regions