Table 3. Look-up table of deregulated miRNA and target genes related to neuropathic human pain disorders or preclinical models of neuropathic pain. For ethical reasons, bilateral CCI was excluded as a model.
| miRNA | Regulation | Target | Gene description | Validation | Pain model | Tissue | Species | Reference |
|---|---|---|---|---|---|---|---|---|
| miR‐15b | ↑ | Bace1 | Beta-secretase 1 | LucA | Oxaliplatin‐induced peripheral neuropathy | DRG | Rat | [72] |
| miR-18a | ↑ | Kcna1; Kcnd3 | Potassium voltage-gated channel subfamily A member 1; Potassium voltage-gated channel subfamily D member 3 | LucA | SNL | DRG | Rat | [73] |
| miR-19a | ↑ | Kcna4; Kcnc4; Kcnq5; Scn1b | Potassium voltage-gated channel subfamily A member 4; Potassium voltage-gated channel subfamily C member 4; Potassium voltage-gated channel subfamily Q member 5; Sodium voltage-gated channel beta subunit 1 | LucA | SNL | DRG | Rat | [73] |
| miR-19b | ↑ | Kcna4; Kcnc4; Kcnq5; Scn1b | Potassium voltage-gated channel subfamily A member 4; Potassium voltage-gated channel subfamily C member 4; Potassium voltage-gated channel subfamily Q member 5; Sodium voltage-gated channel beta subunit 1 | LucA | SNL | DRG | Rat | [74] |
| miR-32-5p | ↑ | Dusp5 | Dual specificity phosphatase 5 | LucA | SNL | Spinal cord / microglia | Rat | [75] |
| miR-92a | ↑ | Kcnc4; Dpp10 | Potassium voltage-gated channel subfamily C member 4; Dipeptidyl peptidase like 10 | LucA | SNL | DRG | Rat | [73] |
| miR-124a | ↑ | SIRT1 | Sirtuin 1 | LucA | Neuropathic pain patients | CD4+ T cells | Human | [51] |
| miR-132-3p | ↑ | GRIA1 | Glutamate ionotropic receptor AMPA type subunit 1 | LucA | Neuropathic pain patients | WBC / sural nerve | Human | [54] |
| miR-132-3p | ↑ | Gria1 | Glutamate ionotropic receptor AMPA type subunit 1 | LucA | SNI | Sural nerve / spinal cord / DRG | Rat | [54] |
| miR-146a-5p | ↑ | Traf6 | TNF receptor-associated factor 6 | LucA | SNL | Spinal astrocytes | Mouse | [76] |
| miR-155 | ↑ | Socs1 | Suppressor of cytokine signalling 1 | LucA | CCI | Spinal cord / microglia | Rat | [77] |
| miR-155 | ↑ | SIRT1 | Sirtuin 1 | LucA | Neuropathic pain patients | CD4+ T cells | Human | [51] |
| miR-183-5p | ↑ | Cldn1 | Claudin 1 | mimic + WB | Perineural injection of sciatic nerve with recombinant tissue plasminogen activator | Sciatic nerve | Rat | [78] |
| miR-195 | ↑ | Ptch1 | Patched 1 | LucA | Infraorbital nerve CCI | Brain stem | Rat | [79] |
| miR-195 | ↑ | Atg14 | Autophagy related 14 | LucA | SNL | Spinal cord / microglia | Rat | [80] |
| miR-199a-3p | ↑ | SERPINE2 | Serpin family E member 2 | LucA | Diabetes type II | Plasma | Human | [55] |
| miR-218 | ↑ | Socs3 | Suppressor of cytokine signalling 3 | LucA | CCI | Spinal cord / microglia | Rat | [81] |
| miR-221 | ↑ | Socs1 | Suppressor of cytokine signalling 1 | LucA | CCI | Spinal cord / microglia | Rat | [82] |
| miR-449a | ↑ | Pparg | Peroxisome proliferator-activated receptor gamma | LucA | SCI | Spinal cord | Rat | [83] |
| miR-455-3p | ↑ | TUBB3 | Tubulin beta 3 class III | mimic + immunofluorescence | HIV-induced polyneuropathy | Plasma | Human | [56] |
| miR-500 | ↑ | Gad1 | Glutamate decarboxylase 1 | LucA | Paclitaxel-induced neuropathic pain | Spinal dorsal horn | Rat | [84] |
| miR-7a | ↓ | Scn2b | Sodium voltage-gated channel beta subunit 2 | LucA | SNL | DRG | Rat | [85] |
| miR-7a | ↓ | Nefl | Neurofilament light | LucA | SNL | DRG | Rat | [86] |
| miR-9 | ↓ | Foxp1 | Forkhead box P1 | mimic + WB | Sciatic nerve crush | DRG | Mouse | [87] |
| miR-19a | ↓ | Mecp2 | Methyl CpG binding protein 2 | LucA | SNI | DRG | Mouse | [88] |
| miR-20b-5p | ↓ | Akt3 | AKT serine/threonine kinase 3 | LucA | CCI | Spinal cord | Rat | [89] |
| miR-21-5p | ↓ | Timp3; Ccl1 | TIMP metallopeptidase inhibitor 3; C-C motif chemokine ligand 1 | LucA | CCI | Spinal cord | Rat | [90] |
| miR-23a-3p | ↓ | Cxcr4 | Chemokine (C-X-C motif) receptor 4 | LucA | SNL | Spinal cord | Mouse | [91] |
| miR-23b | ↓ | Nox4 | NADPH oxidase 4 | LucA | Traumatic SCI (neuropathic pain) | Spinal cord | Mouse | [92] |
| miR-26a-5p | ↓ | Mapk6 | Mitogen-activated protein kinase 6 | LucA | CCI | Spinal cord | Rat | [93] |
| miR-30b | ↓ | Scn9a | Sodium voltage-gated channel alpha subunit 9 | LucA | SNI | DRG | rat | [94] |
| miR-30b | ↓ | Scn3a | Sodium voltage-gated channel alpha subunit 3 | LucA | SNL | DRG | Rat | [95] |
| miR-34a | ↓ | Scn2b; Vamp2 | Sodium voltage-gated channel beta subunit 2; Vesicle-associated membrane protein 2 | LucA | CCI | DRG | Rat | [96] |
| miR-34a | ↓ | XIST; YY1 | X inactive specific transcript; YY1 transcription factor | LucA | CRPS | Blood | Human | [57] |
| miR-34a | ↓ | CRHR1 | Corticotropin releasing hormone receptor 1 | LucA | CRPS | Blood | Human | [53] |
| miR-34c | ↓ | Nlrp3 | NLR family, pyrin domain containing 3 | LucA | CCI | Spinal cord | Mouse | [97] |
| miR-96 | ↓ | Scn3a | Sodium voltage-gated channel alpha subunit 3 | mimic + WB | CCI | DRG | Rat | [98] |
| miR-101 | ↓ | KPNB1 | Karyopherin subunit beta 1 | LucA | Neuropathic pain patients | Plasma / sural nerve | Human | [58] |
| miR-132 | ↓ | Mecp2 | Methyl CpG binding protein 2 | LucA | SNI | DRG | Mouse | [88] |
| miR-141 | ↓ | Hmgb1 | High mobility group box 1 | LucA | CCI | DRG | Rat | [99] |
| miR–142–3p | ↓ | Hmgb1 | High mobility group box 1 | LucA | SNL | DRG | Mouse | [100] |
| miR-145 | ↓ | Akt3 | AKT serine/threonine kinase 3 | LucA | CCI | DRG | Rat | [101] |
| miR-145 | ↓ | Rreb1 | Ras responsive element binding protein 1 | LucA | CCI | Spinal cord | Rat | [102] |
| miR-182-5p | ↓ | Ephb1 | Eph receptor B1 | LucA | CCI | Spinal cord | Mouse | [103] |
| miR-183 | ↓ | Mtor | Mechanistic target of rapamycin kinase | LucA | CCI | Spinal cord | Rat | [104] |
| miR-183 | ↓ | Scn3a; Bdnf | Sodium voltage-gated channel alpha subunit 3; Brain-derived neurotrophic factor | mimic + qPCR | SNL | DRG | Rat | [105] |
| miR-183-5p | ↓ | Kcnk2 | Potassium two pore domain channel subfamily K member 2 (Trek1) | LucA | CCI | DRG | Rat | [106] |
| miR-186-5p | ↓ | Cxcl13 | Chemokine (C-X-C motif) ligand 13 | LucA | SNL | Spinal cord | Mouse | [107] |
| miR-190a-5p | ↓ | Slc17a6 | Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 (Vglut2) | LucA | Diabethic neuropathy | Spinal cord | Mouse | [108] |
| miR-200b | ↓ | Zeb1 | Zinc finger E-box binding homeobox 1 | LucA | CCI | Spinal cord / microglia | Rat | [109] |
| miR-206 | ↓ | Bdnf | Brain-derived neurotrophic factor | LucA | CCI | DRG | Rat | [110] |
| miR-206-3p | ↓ | Hdac4 | Histone deacetylase 4 | LucA | CCI | DRG | Rat | [111] |
| miR-301 | ↓ | Mecp2 | Methyl CpG binding protein 2 | LucA | SNI | DRG | Mouse | [88] |
| miR-338-5p | ↓ | IL6 | Interleukin 6 | LucA | CRPS | Plasma | Human | [41] |
| miR-362-3p | ↓ | Pax2 | Paired box 2 | LucA | SCI | Spinal cord | Rat | [112] |
| miR-429 | ↓ | Zeb1 | Zinc finger E-box binding homeobox 1 | LucA | CCI | Spinal cord/microglia | Rat | [109] |
| miR–449a | ↓ | Trpa1; Kcnma1 | Transient receptor potential cation channel, subfamily A, member 1; Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | mimic + qPCR | SNI | DRG | Mouse | [113] |
| miR-539 | ↓ | Grin2b | Glutamate ionotropic receptor NMDA type subunit 2B | mimic + WB | CCI | ACC | Rat | [114] |
| miR-939 | ↓ | VEGFA | Vascular endothelial growth factor A | LucA | CRPS | Plasma | Human | [52] |
Abbreviations: CCI, chronic constriction injury; CRPS, chronic regional pain syndrome; SCI, spinal cord injury; SNI, spared nerve injury; SNL, sciatic nerve ligation.