Fig. 3.

RNA-Seq analysis (a) MA – plots of all 3 cell lines. Significantly upregulated genes are shown in red, significantly downregulated genes are shown in blue. Dotted lines represent the significance limit at 1.5-fold. Detailed information of genes can be found in Supplementary Table S1-S3 (b) Venn diagrams displaying the overlap of differentially expressed genes identified during RNA-Seq analysis. Overlapping genes can be found in Supplementary Table S4. Overlaps of upregulated and downregulated genes are displayed in (c). (d) PCA of the top 500 genes with the highest variance using vst-normalized counts. Black arrows indicate the change of the DE pool. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)