Fig. 3.

BTK protein levels after in vivo placebo and ibrutinib treatment. (A–F) Protein levels detected on western blot of total BTK (tBTK), BTK phosphorylated at tyrosine 223 (pBTK Y223) and the ratio between total BTK and BTK phosphorylated at tyrosine 223 (ratio pBTK Y223/tBTK) for lysates of cells harvested from organs of placebo (black circles) and ibrutinib (grey squares) treated mice for TCF3-PBX1 positive (A) and TCF3-PBX1 negative (B) engraftments. Mean and SD per treatment group are displayed.