Table 2. Summary of treatment preparation and methods from prior studies.

*Not mentioned in the manuscript

Study	Concentration (units/ml)	Diluent	Number of injection sites	Units per site	Total units per hand	Frequency of treatment (range)	Average follow-up time
Fregene et al., 2009 [3]	50	2.0 ml of normal saline solution	2-4	*	10-100	*	18 months
Neumeister et al., 2009 [18]	5	20 ml of normal saline solution	1-4	*	50-100	One treatment set at baseline; 4 patients (21%) required 2-4 additional injections	13-59 months
Uppal et al., 2014 [8]	20	5 ml of normal saline solution	10	10	100	One treatment set at baseline	6 months
Motegi et al, 2016 [7]	20	2.5 ml of normal saline solution	2	5	10	One treatment set at baseline	16 weeks
Wang et al., 2016 [1]	25	4 ml of 0.9% sodium chloride	9	2.5	22.5	One treatment set at baseline	2 months
Bello et al., 2017 [9]	20	2.5 ml of sterile saline solution	7	5-10	50	One treatment set at baseline	4 months
Medina et al., 2018 [13]	20	5 ml of 0.9% saline serum	8	4-8	32-64	One treatment set at baseline	3 years