Fig. 2.

Caenorhabditis elegans ced-11, and ced-11-like sequences, belong to a previously unrecognized family of TRP channels, the TRPS. TRPM-like and ced-11-like sequences form two distinct clades, with the topology suggesting divergence prior to the Cnidaria–Bilateria split. (A) Maximum likelihood tree showing the relationship between traditional TRPM and TRPS/ced-11-like sequences among those species that have TRPS/ced-11-like species. Full annotated tree available in supplementary figure S1, Supplementary Material online; alternative hypothesis testing in supplementary figures S3 and S4, Supplementary Material online. (B) Left, summary of maximum likelihood analysis and branch support (UFboot) for indicated clades. Right, presence or absence of family in indicated taxa (where Bilateria is Xenacoelomorpha+Nephrozoa). Solid lines in color indicate that the TRP family is present in the indicated taxon, whereas dashed lines in gray indicate that no sequences were found for the indicated taxon. Family specific duplication/loss events summarized in figures 4 and 5.