Fig. 5.

Summary of the evolution of TRPM channels. The TRPM family is widely conserved and is present in all phyla surveyed except Tardigrada. Figure derived from consensus topologies in reconciled maximum likelihood trees generated against TRPM database sequences, with branch support for duplication branches extracted from phylograms without Xenacoelomorpha (supplementary figs. S13–S17, Supplementary Material online). Asterisk (*) indicates that a duplication branch most frequently formed due to rearrangement (initial UFboot branch support <95). Here, phyla were expanded/collapsed to more easily show TRPM diversification: Chordata was expanded into Cephalochordata (lancelets), Tunicata, and Vertebrata; Echinodermata and Hemichordata were collapsed into Ambulacraria; and Annelida, Nemertea, Brachiopoda, Phoronida, and Mollusca were collapsed into Lophotrochozoa. Red dots indicate duplication events. Dashed lines in color indicate sequences considered incertae sedis. Dashed lines in gray indicate that no sequences were found for the indicated taxon and were inferred to be loss events.