Table 1.

Summary of the known allosteric binding sites in the LBD of bacterial pLGICs (GLIC, ELIC, sTeLIC, and DeCLIC) with their ligands and PDB ID

		Allosteric site		Loop F
pLGIC, State	Pore, PDB	Suborthosteric	Vestibular	Interfacial site	Deep site
GLIC	Open	Br-Acetate: 4QH1	Br-Acetate: 4QH1	Water network: 6HZW; H+ (E35, T158)	Xenon: 4ZZC
Open	4HFI	Succinate: 6HJZ	Succinate: 6HJZ
GLIC	Closed	Empty	Empty	Empty	Bromoform:
Closed	4NPQ				MD simulations
sTeLIC	Open	Empty	4-Br-cinnamate: 6FLI	Empty	Closed
Open	6FL9
ELIC	Closed	Zopiclone: 4A97	Flurazepam: 2YOE	Ba2+: 2YN6	Bromoform: 3ZKR
Semiclosed	2VL0	Br-Flurazepam: 4A98		Chlorpromazine: 5LG3
		Acetylcholine: 3RQW
		Bromoethanol: 5SXV
DeCLIC	Open	Empty	Empty	Empty	Empty
Open	6V4A
DeCLIC	Closed	Remodeled/larger	Remodeled/smaller	Ca2+	Closed
Closed	6V4S