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. 2020 Jun 3;117(24):13428–13436. doi: 10.1073/pnas.2001569117

Fig. 1.

Fig. 1.

Tandem peptides encapsulate immunostimulatory oligonucleotides in nanocomplexes. (A) Schematic of iTPNC formation with various oligonucleotide cargoes encapsulated with targeted tandem peptides. (B–D) DLS measurements (Left) of hydrodynamic diameter (purple bars) and polydispersity index (PDI, red curves) and TEM images (Right) of iTPNCs formulated with oligodeoxyribonucleotide TLR9 ligands ODN 1585 (B), ODN 1826 (C), and ODN 2395 (D) encapsulated with various ratios of peptide to cargo. (E–G) DLS measurements (Left) of hydrodynamic diameter (green bars) and PDI (red curves) and TEM images (Right) of iTPNCs formulated with oligoribonucleotide TLR ligands poly(I:C) (E), ssPolyU (F), and ORN Sa19 (G) encapsulated with various ratios of peptide to cargo. (Scale bars, 100 nm.)