Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 29;117(24):13740–13749. doi: 10.1073/pnas.1922884117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

PMC Copyright notice

Fig. 1. — Loss of IL-6 accelerates inflammation and lymphomagenesis in HBZ-Tg mice. (A) Incidence of dermatitis in WT (blue; n = 65), HBZ-Tg (yellow; n = 39), IL-6 KO (green; n = 72), and HBZ-Tg/IL-6 KO (red; n = 42) mice. These mice were observed for 1 y (log-rank test). (B) Overall survival of each strain: WT, n = 13; HBZ-Tg, n = 13; IL-6 KO, n = 14; HBZ-Tg/IL-6 KO, n = 24. These mice were observed for 2 y (log-rank test). (C) Incidence of lymphoma in each strain at age 24 wk. (D) Histopathological analysis of primary lymphoma in lymph node and spleen of an HBZ-Tg/IL-6 KO mouse. (E) Incidence of dermatitis in IL-6R^fl/fl (blue; n = 15), HBZ-Tg/IL-6R^fl/fl (yellow; n = 10), CD4-Cre/IL-6R^fl/fl (green; n = 7), and HBZ-Tg/CD4-Cre/IL-6R^fl/fl (red; n = 8) mice (log-rank test). (F) Incidence of dermatitis in IL-6R^fl/fl (blue; n = 20), HBZ-Tg/IL-6R^fl/fl (yellow; n = 14), LysM-Cre/IL-6R^fl/fl (green; n = 23), and HBZ-Tg/LysM-Cre/IL-6R^fl/fl (red; n = 17) mice (log-rank test).