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. 2020 Jun 2;117(24):13267–13274. doi: 10.1073/pnas.1922139117

Scheme 4.

Scheme 4.

Partial mechanism for 2-aminooxazole synthesis. The first step is addition of cyanamide to the carbonyl of glycolaldehyde (Top). In the presence of excess HCN, the glycolaldehyde-derived glyceronitrile forms and inhibits the reaction (Bottom).