Table 1.
Characteristics of studies
| Author and year | Specie/ strain | Total n | Source of CM-Dosage | Application of MSC-CM |
|---|---|---|---|---|
| (Ando et al.,2014) | Mice / ICR | unclear | hMSCs − 20 μl | Distraction osteogenesis of tibia |
| Chang et al.,2015) | Rats/ Sprague-Dawley | 21 | rMSCs-1 ml | Circular calvarial bone defect of 5 mm diameter |
| (Furuta et al.,2016) | Mice/ (C57BL/6),CD9 | 77 | hMSCs-100 μl | Femur fracture |
| (Inukai et al.,2013) | Dogs / hybrid | 18 | hMSCs-300 μl | Critical-size, box-type, one-wall intrabony defects (width 4 mm, height 5 mm) |
| (Katagiri et al.,2013) | Rats / Wistar/ST | 24 | hMSCs-NR | Circular calvarial bone defect of 5 mm diameter |
| (Katagiri et al.,2015) | Rabbits/ (JW/CSK) | 15 | hMSCs-NR | Bilateral cavity in the maxillary sinus (lateral window of 5 × 5 mm) |
| (Katagiri et al.,2016) | Humans | 8 | BM-hMSCs-3 ml | Maxillary sinus floor elevation (< 5 mm of residual bone) |
| Katagiri et al.,2017b) | Rats /Wistar/ST | 24 | hMSCs-NR | Circular calvarial bone defect of 5 mm diameter |
| (Katagiri et al.,2017a) | Humans | 6 | BM-hMSCs-3 ml | Maxillary sinus floor elevation (< 5 mm of residual bone) |
| (Katagiri et al.,2017c) | Rats / Wistar/ST | 40 | BM-hMSCs-30 μl | Circular calvarial bone defect of 5 mm diameter |
| (Kawai et al.,2015) | Rats /Wistar/ST | unclear | BM-hMSCs-30 μl | Periodontal defect of 1 mm diameter at palatal side of the first molar |
| (Linero & Chaparro,2014) | Rabbits / New Zealand | 19 | Ad-hMSCs-16,6 μl | Bilateral mandibular bone defects of 10 mm diameter |
| (Ogata et al.,2015) | Rats / Wistar/ ST | 24 | hMSCs-1 ml | Exposed bone after tooth extraction in rats with BRONJ |
| (Osugi et al.,2012) | Ratas Wistar/ST | 40 | BM-hMSCs-6 ml | Circular calvarial bone defect of 5 mm diameter |
| (Qin et al.,2016) | Rats / Sprague Dawley (SD) | 6 | BM-hMSCs (Evs) -100 μg | Circular calvarial bone defect of 5 mm diameter |
| (Sanchooli et al.,2017) | Rats / Wistar/ST | 24 | Ad-rMSCs-NR | Circular calvarial bone defect of 5 mm diameter in rats with hypothyroidism |
| (Tsuchiya et al.,2013) | Rats /Sprague- Dawley | 15 | BM-rMSCs-1 mg/ml | Implant in insertion socket of 1,5 mm diameter created on the femur |
| (Tsuchiya et al.,2015) | Rats / Sprague-Dawley | 24 | BM-rMSCs-NR | Circular calvarial bone defect of 8 mm diameter |
| (Wang et al.,2012b) | Rats /Sprague–Dawley (SD) | unclear | hMSCs-100 μl | Fracture - Bone defect of 2 mm in the middle third of the fibula in rats with diabetes |
| (Wang et al.,2015) | Rats / Sprague-Dawley (SD) | 8 | hUCMSCs-10 μg | Circular calvarial bone defect of 5 mm diameter |
| (Xu et al.,2016) | Rats / SD | 24 | F-hMSCs-100 μl | Distraction osteogenesis of tibia transverse osteotomy |
hMSCS Human mesenchymal stem cells, rMSCS Rat mesenchymal stem cells, BM Bone marrow, Ad adipose tissue, hUCMSCs Mesenchymal stem cells derived from human umbilical cord, F-hMSCs human fetal mesenchymal stem cells. Evs Extracellular vesicles. NR No report