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Expanded Hill equation analysis of pharmacological activity of hydromethylthionine on change in ACE-R, FAQ, and WBV using model-derived least squares mean and standard error estimates of change over 52 weeks for clinical (a,b) and MRI volumetric (c) endpoints according to plasma concentration group (8 mg/day) or dose (200 mg/day). Scales at the top of each panel indicate actual doses or calculated theoretical intermediate doses.
