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Schematic of aggrecan. KS chains are shown as green strings, CS chains as violet strings. Major ADAMTS‐5 cleavage sites are reported. Sequences are for human aggrecan (UniProt ID: P16112). In brackets the preferential order of cleavage is reported36.Cleavages at Glu2053↓Leu2054 and Glu1953↓Ala1954 (indicated by 2') follow the primary cleavage at Glu1848↓Gly1849 and represent C‐terminal processing events occurring in parallel to cleavage at Glu1679↓ Gly1680.
