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. 2019 Oct 14;69(7):1229–1238. doi: 10.1136/gutjnl-2019-319322

Figure 3.

Figure 3

The microbiota of Prader-Willi syndrome (PWS) patients promotes improved insulin tolerance after transfer to germ-free mice. Phenotype of mice transplanted with microbiota from a obese control (OC) and a PWS donor (donor-pair 1, see online supplementary table 10). (A) Body weight gain after colonisation, (B) epididymal white adipose (EWAT) weight, (C) distribution of adipocyte cell sizes, (D) fat/lean mass ratio, (E) liver weight, (F and G) insulin tolerance, (H) fasting glucose, (I and J) glucose tolerance, (K) fasting insulin and insulin 15 min after glucose injection, (L) interleukin 6 levels. Mean±SEM are plotted. n=7 to 8 mice per group. **p<0.01 according to two-way analysis of variance for repeated measurement (panel F) and t-test (panel G). AUC, area under the curve; GTT, glucose tolerance test.