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. 2020 Jun 1;117(24):13238–13247. doi: 10.1073/pnas.1917569117

Fig. 4.

Fig. 4.

Mechanism of formation of a condensate composed of scaffolds and clients (67% 3-valency scaffolds + 33% 2-valency high-affinity clients) at a value of the normalized inverse interaction strength equal to 0.85 (dashed line in Fig. 3A). Each panel gives a plot of the condensation order parameter for scaffolds (red), QS(L), and clients (blue), QC(L), versus the direction of the largest dimension, L, of the simulation box, as well as the value of the relative enrichment of scaffolds over clients in the newly formed condensates χS/C. Simulation snapshots (scaffolds as red spheres and clients as blue spheres) for the different stages of the condensate-formation process are also provided: (A) initial well-mixed configuration, (B) nucleation, (C) growth, and (D) equilibrium condensate.