FIG 8.
Coordination among ICP0 active domains in its recognition and degradation of PML II. The pink rod represents the 775-amino acid ICP0 cDNA; green oval with an R represents the RING finger domain located at residues 116 to 156; yellow squares represent the three proline-rich ND10-fusion segments (FS1, FS2, and FS3) identified in a previous report (44); orange ovals represent SIMs in the central and C-terminal regions of ICP0, with SIM362-364 located within FS2; blue rectangle with NLS inside represents nuclear localization sequence at residues 500 to 506; dark blue rectangles beneath ICP0 indicate the positions of USP7- and CoREST-binding sites.