FIG 1.

DINO levels correlate with TP53 levels in HPV oncoprotein-expressing cells. HFK populations with stable expression of HPV16 E6 and/or E7 or a dominant negative TP53 minigene (dnTP53) were validated by determining the levels of TP53 and E7 by Western blotting. DINO levels were assessed in these HFK populations by qRT-PCR assays. Levels shown are relative to those for control vector-transduced HFKs. The bar graph shows means and standard errors of the means (SEM; n = 3) calculated from a single representative experiment. ***, P < 0.001 (Student's t test). Similar results were obtained with three independently derived HFK populations.